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flufenamic acid
Flufenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs〔 Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.〔 Flufenamic acid is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.
It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects.〔Jeffrey K. Aronson. Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Elsevier, 2009 ISBN 9780080932941〕 It is generally not available in the US.〔NIH LiverTox Database (Mefenamic Acid ) Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"〕 It is available in some Asian and European countries as a generic.〔Drugs.com (Drugs.com international listings for flufenamic acid ) Page accessed July 3, 2015〕
Scientists led by Claude Winder from Parke-Davis invented flufenamic acid in 1963, along with fellow members of the class, mefenamic acid in 1961 and meclofenamate sodium in 1964.〔Whitehouse M. Drugs to Treat Inflammation: A Historical Overview. pp 707-729 in Frontiers in Medicinal Chemistry , Volume 4. Eds Rahman A, et al. Bentham Science Publishers, 2009 ISBN 9781608052073〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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